| 19 February 2022 | ||||||
| 12:30 | West Ham United |  | 1:1 |  | Newcastle United |  |
| 15:00 | Arsenal |  | 2:1 |  | Brentford | |
| 15:00 | Aston Villa |  | 0:1 |  | Watford | |
| 15:00 | Brighton |  | 0:3 |  | Burnley | |
| 15:00 | Crystal Palace |  | 0:1 |  | Chelsea | |
| 15:00 | Liverpool |  | 3:1 |  | Norwich City | |
| 15:00 | Southampton |  | 2:0 |  | Everton | |
| 17:30 | Manchester City |  | 2:3 |  | Tottenham Hotspur | |
| 20 February 2022 | ||||||
| 14:00 | Leeds United |  | 2:4 |  | Manchester United | |
| 16:30 | Wolverhampton Wanderers |  | 2:1 |  | Leicester City | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 26 | 20 | 3 | 3 | 63:17 | 63 |
| 2. |  | Liverpool | 26 | 18 | 6 | 2 | 70:20 | 60 |
| 3. |  | Chelsea | 25 | 14 | 8 | 3 | 49:18 | 50 |
| 4. |  | Manchester United | 26 | 13 | 7 | 6 | 44:34 | 46 |
| 5. |  | Arsenal | 24 | 14 | 3 | 7 | 38:27 | 45 |
| 6. |  | West Ham United | 26 | 12 | 6 | 8 | 45:34 | 42 |
| 7. |  | Wolverhampton Wanderers | 25 | 12 | 4 | 9 | 24:20 | 40 |
| 8. |  | Tottenham Hotspur | 24 | 12 | 3 | 9 | 31:32 | 39 |
| 9. |  | Brighton | 25 | 7 | 12 | 6 | 25:28 | 33 |
| 10. |  | Southampton | 25 | 7 | 11 | 7 | 32:37 | 32 |
| 11. |  | Crystal Palace | 26 | 6 | 11 | 9 | 36:37 | 29 |
| 12. |  | Leicester City | 23 | 7 | 6 | 10 | 37:43 | 27 |
| 13. |  | Aston Villa | 24 | 8 | 3 | 13 | 31:37 | 27 |
| 14. |  | Brentford | 26 | 6 | 6 | 14 | 27:42 | 24 |
| 15. |  | Leeds United | 25 | 5 | 8 | 12 | 29:56 | 23 |
| 16. |  | Everton | 23 | 6 | 4 | 13 | 28:40 | 22 |
| 17. |  | Newcastle United | 24 | 4 | 10 | 10 | 26:45 | 22 |
| 18. |  | Burnley | 23 | 3 | 11 | 9 | 21:29 | 20 |
| 19. |  | Watford | 25 | 5 | 3 | 17 | 25:47 | 18 |
| 20. |  | Norwich City | 25 | 4 | 5 | 16 | 15:53 | 17 |
Stadium: City of Manchester Stadium (Manchester), 53,201 audience (97% full)
Season: 2021-22, 26 round, 2022-02-19 17:30
2:3
(1:1)
| 4' |  | 0:1 | Dejan Kulusevski |
| 33' | | 1:1 | Ilkay Guendogan |
| 59' | | 1:2 | Harry Kane |
| 64' |  | Pierre Emile Hojbjerg | |
| 76' | | Cristian Romero | |
| 80' | | Hugo Lloris | |
| 90+2' |  | 2:2 | Riyad Mahrez |
| 90+5' | | 2:3 | Harry Kane |
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