| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 22 | 18 | 2 | 2 | 54:13 | 56 |
| 2. |  | Chelsea | 22 | 12 | 7 | 3 | 45:17 | 43 |
| 3. |  | Liverpool | 20 | 12 | 6 | 2 | 52:18 | 42 |
| 4. |  | West Ham United | 21 | 11 | 4 | 6 | 39:27 | 37 |
| 5. |  | Arsenal | 20 | 11 | 2 | 7 | 33:25 | 35 |
| 6. |  | Tottenham Hotspur | 18 | 10 | 3 | 5 | 23:20 | 33 |
| 7. |  | Manchester United | 19 | 9 | 4 | 6 | 30:27 | 31 |
| 8. |  | Wolverhampton Wanderers | 20 | 9 | 4 | 7 | 17:15 | 31 |
| 9. |  | Brighton | 19 | 6 | 9 | 4 | 20:20 | 27 |
| 10. |  | Leicester City | 18 | 7 | 4 | 7 | 31:33 | 25 |
| 11. |  | Southampton | 21 | 5 | 9 | 7 | 25:33 | 24 |
| 12. |  | Crystal Palace | 20 | 5 | 8 | 7 | 28:29 | 23 |
| 13. |  | Brentford | 20 | 6 | 5 | 9 | 24:30 | 23 |
| 14. |  | Aston Villa | 19 | 7 | 1 | 11 | 25:30 | 22 |
| 15. |  | Everton | 19 | 5 | 4 | 10 | 23:33 | 19 |
| 16. |  | Leeds United | 19 | 4 | 7 | 8 | 21:37 | 19 |
| 17. |  | Watford | 19 | 4 | 2 | 13 | 23:37 | 14 |
| 18. |  | Norwich City | 21 | 3 | 4 | 14 | 10:45 | 13 |
| 19. |  | Newcastle United | 20 | 1 | 9 | 10 | 20:43 | 12 |
| 20. |  | Burnley | 17 | 1 | 8 | 8 | 16:27 | 11 |
| Burnley | | : | | Leicester City |  | |
| 15 January 2022 | ||||||
| 12:30 | Manchester City | | 1:0 | | Chelsea | |
| 15:00 | Newcastle United | | 1:1 | | Watford | |
| 15:00 | Norwich City | | 2:1 | | Everton | |
| 15:00 | Wolverhampton Wanderers | | 3:1 | | Southampton | |
| 17:30 | Aston Villa | | : | | Manchester United | |
| 20:00 | Brighton | | : | | Crystal Palace | |
| 16 January 2022 | ||||||
| 14:00 | Liverpool | | : | | Brentford | |
| 14:00 | West Ham United | | : | | Leeds United | |
| 16:30 | Tottenham Hotspur | | : | | Arsenal | |
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