| 12 March 2022 | ||||||
| 12:30 | Brighton |  | 0:2 |  | Liverpool |  |
| 15:00 | Brentford |  | 2:0 |  | Burnley | |
| 17:30 | Manchester United |  | 3:2 |  | Tottenham Hotspur | |
| 13 March 2022 | ||||||
| 14:00 | Chelsea |  | 1:0 |  | Newcastle United | |
| 14:00 | Everton |  | 0:1 |  | Wolverhampton Wanderers | |
| 14:00 | Leeds United |  | 2:1 |  | Norwich City | |
| 14:00 | Southampton |  | 1:2 |  | Watford | |
| 14:00 | West Ham United |  | 2:1 |  | Aston Villa | |
| 14 March 2022 | ||||||
| 20:00 | Crystal Palace |  | 0:0 |  | Manchester City | |
| 13 August 2022 | ||||||
| 15:00 | Arsenal |  | 2:0 |  | Leicester City | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 28 | 22 | 3 | 3 | 68:18 | 69 |
| 2. |  | Liverpool | 28 | 20 | 6 | 2 | 73:20 | 66 |
| 3. |  | Chelsea | 26 | 15 | 8 | 3 | 53:18 | 53 |
| 4. |  | Arsenal | 25 | 15 | 3 | 7 | 41:29 | 48 |
| 5. |  | Manchester United | 28 | 13 | 8 | 7 | 45:38 | 47 |
| 6. |  | West Ham United | 28 | 13 | 6 | 9 | 46:35 | 45 |
| 7. |  | Tottenham Hotspur | 26 | 14 | 3 | 9 | 40:32 | 45 |
| 8. |  | Wolverhampton Wanderers | 28 | 13 | 4 | 11 | 28:23 | 43 |
| 9. |  | Aston Villa | 27 | 11 | 3 | 13 | 40:37 | 36 |
| 10. |  | Southampton | 28 | 8 | 11 | 9 | 35:43 | 35 |
| 11. |  | Crystal Palace | 28 | 7 | 12 | 9 | 39:38 | 33 |
| 12. |  | Leicester City | 25 | 9 | 6 | 10 | 40:43 | 33 |
| 13. |  | Brighton | 28 | 7 | 12 | 9 | 26:34 | 33 |
| 14. |  | Newcastle United | 27 | 7 | 10 | 10 | 32:47 | 31 |
| 15. |  | Brentford | 29 | 8 | 6 | 15 | 32:45 | 30 |
| 16. |  | Leeds United | 28 | 5 | 8 | 15 | 29:64 | 23 |
| 17. |  | Everton | 25 | 6 | 4 | 15 | 28:46 | 22 |
| 18. |  | Burnley | 27 | 3 | 12 | 12 | 22:38 | 21 |
| 19. |  | Watford | 28 | 5 | 4 | 19 | 27:54 | 19 |
| 20. |  | Norwich City | 27 | 4 | 5 | 18 | 16:58 | 17 |
Stadium: Old Trafford (Manchester), 73,458 audience (97% full)
Season: 2021-22, 29 round, 2022-03-12 17:30
3:2
(2:1)
| 12' |  | 1:0 | Cristiano Ronaldo |
| 30' |  | Eric Dier | |
| 35' |  | 1:1 | Harry Kane |
| 35' | | David de Gea | |
| 38' | | 2:1 | Cristiano Ronaldo |
| 72' | | 2:2 | Harry Maguire |
| 81' | | 3:2 | Cristiano Ronaldo |
| 85' | | Paul Pogba |
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