| 27 November 2021 | ||||||
| 12:30 | Arsenal |  | 2:0 |  | Newcastle United |  |
| 15:00 | Liverpool |  | 4:0 |  | Southampton | |
| 15:00 | Norwich City |  | 0:0 |  | Wolverhampton Wanderers | |
| 28 November 2021 | ||||||
| 14:00 | Leicester City |  | 4:2 |  | Watford | |
| 14:00 | Manchester City |  | 2:1 |  | West Ham United | |
| 16:30 | Chelsea |  | 1:1 |  | Manchester United | |
| 23 February 2022 | ||||||
| 19:30 | Burnley |  | 1:0 |  | Tottenham Hotspur | |
| 20 August 2022 | ||||||
| 15:00 | Crystal Palace |  | 1:2 |  | Aston Villa | |
| 27 August 2022 | ||||||
| 15:00 | Brentford |  | 1:0 |  | Everton | |
| 15:00 | Brighton |  | 0:0 |  | Leeds United | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Chelsea | 13 | 9 | 3 | 1 | 31:5 | 30 |
| 2. |  | Manchester City | 13 | 9 | 2 | 2 | 27:7 | 29 |
| 3. |  | Liverpool | 13 | 8 | 4 | 1 | 39:11 | 28 |
| 4. |  | West Ham United | 13 | 7 | 2 | 4 | 24:16 | 23 |
| 5. |  | Arsenal | 13 | 7 | 2 | 4 | 15:17 | 23 |
| 6. |  | Wolverhampton Wanderers | 13 | 6 | 2 | 5 | 12:12 | 20 |
| 7. |  | Tottenham Hotspur | 12 | 6 | 1 | 5 | 11:17 | 19 |
| 8. |  | Manchester United | 13 | 5 | 3 | 5 | 21:22 | 18 |
| 9. |  | Brighton | 13 | 4 | 6 | 3 | 12:14 | 18 |
| 10. |  | Leicester City | 13 | 5 | 3 | 5 | 20:23 | 18 |
| 11. |  | Crystal Palace | 13 | 3 | 7 | 3 | 19:19 | 16 |
| 12. |  | Brentford | 13 | 4 | 4 | 5 | 17:17 | 16 |
| 13. |  | Aston Villa | 13 | 5 | 1 | 7 | 18:21 | 16 |
| 14. |  | Everton | 13 | 4 | 3 | 6 | 16:20 | 15 |
| 15. |  | Southampton | 13 | 3 | 5 | 5 | 11:18 | 14 |
| 16. |  | Watford | 13 | 4 | 1 | 8 | 18:24 | 13 |
| 17. |  | Leeds United | 13 | 2 | 6 | 5 | 12:20 | 12 |
| 18. |  | Burnley | 12 | 1 | 6 | 5 | 14:20 | 9 |
| 19. |  | Norwich City | 13 | 2 | 3 | 8 | 7:27 | 9 |
| 20. |  | Newcastle United | 13 | 0 | 6 | 7 | 15:29 | 6 |
Stadium: City of Manchester Stadium (Manchester), 52,571 audience (95% full)
Season: 2021-22, 13 round, 2021-11-28 14:00
2:1
(1:0)
| 29' |  | Aymeric Laporte | |
| 33' |  | 1:0 | Ilkay Guendogan |
| 61' | | João Cancelo | |
| 90' | | 2:0 | Fernandinho |
| 90+4' | | 2:1 | Manuel Lanzini |
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