| 26 December 2021 | ||||||
| 15:00 | Tottenham Hotspur |  | 3:0 |  | Crystal Palace |  |
| 15:00 | West Ham United |  | 2:3 |  | Southampton | |
| 15:00 | Manchester City |  | 6:3 |  | Leicester City | |
| 15:00 | Norwich City |  | 0:5 |  | Arsenal | |
| 17:30 | Aston Villa |  | 1:3 |  | Chelsea | |
| 20:00 | Brighton |  | 2:0 |  | Brentford | |
| 27 December 2021 | ||||||
| 20:00 | Newcastle United |  | 1:1 |  | Manchester United | |
| 23 February 2022 | ||||||
| 19:45 | Liverpool |  | 6:0 |  | Leeds United | |
| 10 March 2022 | ||||||
| 19:30 | Wolverhampton Wanderers |  | 4:0 |  | Watford | |
| 06 April 2022 | ||||||
| 19:30 | Burnley |  | 3:2 |  | Everton | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 19 | 15 | 2 | 2 | 50:12 | 47 |
| 2. |  | Liverpool | 18 | 12 | 5 | 1 | 50:15 | 41 |
| 3. |  | Chelsea | 19 | 12 | 5 | 2 | 42:13 | 41 |
| 4. |  | Arsenal | 19 | 11 | 2 | 6 | 32:23 | 35 |
| 5. |  | Tottenham Hotspur | 16 | 9 | 2 | 5 | 21:19 | 29 |
| 6. |  | West Ham United | 18 | 8 | 4 | 6 | 30:24 | 28 |
| 7. |  | Manchester United | 17 | 8 | 4 | 5 | 27:25 | 28 |
| 8. |  | Wolverhampton Wanderers | 18 | 7 | 4 | 7 | 13:14 | 25 |
| 9. |  | Brighton | 17 | 5 | 8 | 4 | 16:17 | 23 |
| 10. |  | Leicester City | 17 | 6 | 4 | 7 | 30:33 | 22 |
| 11. |  | Aston Villa | 18 | 7 | 1 | 10 | 24:28 | 22 |
| 12. |  | Crystal Palace | 18 | 4 | 8 | 6 | 23:26 | 20 |
| 13. |  | Brentford | 17 | 5 | 5 | 7 | 21:24 | 20 |
| 14. |  | Southampton | 18 | 4 | 8 | 6 | 19:28 | 20 |
| 15. |  | Everton | 17 | 5 | 4 | 8 | 20:28 | 19 |
| 16. |  | Leeds United | 18 | 3 | 7 | 8 | 18:36 | 16 |
| 17. |  | Watford | 16 | 4 | 1 | 11 | 21:31 | 13 |
| 18. |  | Burnley | 15 | 1 | 8 | 6 | 14:21 | 11 |
| 19. |  | Newcastle United | 19 | 1 | 8 | 10 | 19:42 | 11 |
| 20. |  | Norwich City | 18 | 2 | 4 | 12 | 8:39 | 10 |
Stadium: City of Manchester Stadium (Manchester), 53,226 audience (97% full)
Season: 2021-22, 19 round, 2021-12-26 15:00
6:3
(4:0)
| 5' |  | 1:0 | Kevin De Bruyne |
| 14' |  | 2:0 | Riyad Mahrez |
| 21' | | 3:0 | Ilkay Guendogan |
| 25' | | 4:0 | Raheem Sterling |
| 45' |  | Jannik Vestergaard | |
| 55' | | 4:1 | James Maddison |
| 59' | | 4:2 | Ademola Lookman |
| 66' | | 4:3 | Kelechi Iheanacho |
| 69' | | 5:3 | Aymeric Laporte |
| 76' | | James Maddison | |
| 87' | | 6:3 | Raheem Sterling |
| 90+1' | | Fernandinho |
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