| 11 September 2021 | ||||||
| 12:30 | Crystal Palace |  | 3:0 |  | Tottenham Hotspur |  |
| 15:00 | Arsenal |  | 1:0 |  | Norwich City | |
| 15:00 | Brentford |  | 0:1 |  | Brighton | |
| 15:00 | Leicester City |  | 0:1 |  | Manchester City | |
| 15:00 | Manchester United |  | 4:1 |  | Newcastle United | |
| 15:00 | Southampton |  | 0:0 |  | West Ham United | |
| 15:00 | Watford |  | 0:2 |  | Wolverhampton Wanderers | |
| 17:30 | Chelsea |  | 3:0 |  | Aston Villa | |
| 12 September 2021 | ||||||
| 16:30 | Leeds United |  | 0:3 |  | Liverpool | |
| 13 September 2021 | ||||||
| 20:00 | Everton |  | 3:1 |  | Burnley | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester United | 4 | 3 | 1 | 0 | 11:3 | 10 |
| 2. |  | Chelsea | 4 | 3 | 1 | 0 | 9:1 | 10 |
| 3. |  | Liverpool | 4 | 3 | 1 | 0 | 9:1 | 10 |
| 4. |  | Everton | 4 | 3 | 1 | 0 | 10:4 | 10 |
| 5. |  | Manchester City | 4 | 3 | 0 | 1 | 11:1 | 9 |
| 6. |  | Brighton | 4 | 3 | 0 | 1 | 5:3 | 9 |
| 7. |  | Tottenham Hotspur | 4 | 3 | 0 | 1 | 3:3 | 9 |
| 8. |  | West Ham United | 4 | 2 | 2 | 0 | 10:5 | 8 |
| 9. |  | Leicester City | 4 | 2 | 0 | 2 | 4:6 | 6 |
| 10. |  | Brentford | 4 | 1 | 2 | 1 | 3:2 | 5 |
| 11. |  | Crystal Palace | 4 | 1 | 2 | 1 | 5:5 | 5 |
| 12. |  | Aston Villa | 4 | 1 | 1 | 2 | 5:7 | 4 |
| 13. |  | Wolverhampton Wanderers | 4 | 1 | 0 | 3 | 2:3 | 3 |
| 14. |  | Southampton | 4 | 0 | 3 | 1 | 4:6 | 3 |
| 15. |  | Watford | 4 | 1 | 0 | 3 | 3:7 | 3 |
| 16. |  | Arsenal | 4 | 1 | 0 | 3 | 1:9 | 3 |
| 17. |  | Leeds United | 4 | 0 | 2 | 2 | 4:11 | 2 |
| 18. |  | Burnley | 4 | 0 | 1 | 3 | 3:8 | 1 |
| 19. |  | Newcastle United | 4 | 0 | 1 | 3 | 5:12 | 1 |
| 20. |  | Norwich City | 4 | 0 | 0 | 4 | 1:11 | 0 |
Stadium: St Mary's Stadium (Southampton), 30,000 audience (92% full)
Season: 2021-22, 4 round, 2021-09-11 15:00
0:0
(0:0)
| 13' |  | Oriol Romeu | |
| 71' | | Michail Antonio | |
| 71' | | Jack Stephens | |
| 73' | | Declan Rice | |
| 90+2' | | Mohammed Salisu | |
| 90+5' |  | Michail Antonio | |
| 90+5' | | Michail Antonio |
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