| 12 February 2022 | ||||||
| 12:30 | Manchester United |  | 1:1 |  | Southampton |  |
| 15:00 | Brentford |  | 0:0 |  | Crystal Palace | |
| 15:00 | Everton |  | 3:0 |  | Leeds United | |
| 15:00 | Watford |  | 0:2 |  | Brighton | |
| 17:30 | Norwich City |  | 0:4 |  | Manchester City | |
| 13 February 2022 | ||||||
| 14:00 | Burnley |  | 0:1 |  | Liverpool | |
| 14:00 | Newcastle United |  | 1:0 |  | Aston Villa | |
| 16:30 | Leicester City |  | 2:2 |  | West Ham United | |
| 20 April 2022 | ||||||
| 19:45 | Chelsea |  | 2:4 |  | Arsenal | |
| 20 August 2022 | ||||||
| 12:30 | Tottenham Hotspur |  | 0:2 |  | Wolverhampton Wanderers | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 25 | 20 | 3 | 2 | 61:14 | 63 |
| 2. |  | Liverpool | 24 | 16 | 6 | 2 | 61:19 | 54 |
| 3. |  | Chelsea | 24 | 13 | 8 | 3 | 48:18 | 47 |
| 4. |  | Manchester United | 25 | 12 | 7 | 6 | 40:32 | 43 |
| 5. |  | West Ham United | 25 | 12 | 5 | 8 | 44:33 | 41 |
| 6. |  | Arsenal | 22 | 12 | 3 | 7 | 34:25 | 39 |
| 7. |  | Wolverhampton Wanderers | 23 | 11 | 4 | 8 | 21:17 | 37 |
| 8. |  | Tottenham Hotspur | 22 | 11 | 3 | 8 | 28:29 | 36 |
| 9. |  | Brighton | 24 | 7 | 12 | 5 | 25:25 | 33 |
| 10. |  | Southampton | 24 | 6 | 11 | 7 | 30:37 | 29 |
| 11. |  | Leicester City | 22 | 7 | 6 | 9 | 36:41 | 27 |
| 12. |  | Aston Villa | 23 | 8 | 3 | 12 | 31:36 | 27 |
| 13. |  | Crystal Palace | 24 | 5 | 11 | 8 | 31:34 | 26 |
| 14. |  | Brentford | 25 | 6 | 6 | 13 | 26:40 | 24 |
| 15. |  | Leeds United | 23 | 5 | 8 | 10 | 27:46 | 23 |
| 16. |  | Everton | 22 | 6 | 4 | 12 | 27:37 | 22 |
| 17. |  | Newcastle United | 23 | 4 | 9 | 10 | 25:44 | 21 |
| 18. |  | Norwich City | 24 | 4 | 5 | 15 | 14:50 | 17 |
| 19. |  | Watford | 23 | 4 | 3 | 16 | 23:43 | 15 |
| 20. |  | Burnley | 21 | 1 | 11 | 9 | 17:29 | 14 |
Stadium: Old Trafford (Manchester), 73,084 audience (96% full)
Season: 2021-22, 25 round, 2022-02-12 12:30
1:1
(1:0)
| 16' |  | Marcus Rashford | |
| 21' |  | 1:0 | Jadon Sancho |
| 31' | | Scott McTominay | |
| 48' | | 1:1 | Che Adams |
| 85' | | Paul Pogba | |
| 90' | | Jesse Lingard |
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