| 02 April 2022 | ||||||
| 12:30 | Liverpool |  | 2:0 |  | Watford |  |
| 15:00 | Brighton |  | 0:0 |  | Norwich City | |
| 15:00 | Burnley |  | 0:2 |  | Manchester City | |
| 15:00 | Chelsea |  | 1:4 |  | Brentford | |
| 15:00 | Leeds United |  | 1:1 |  | Southampton | |
| 15:00 | Wolverhampton Wanderers |  | 2:1 |  | Aston Villa | |
| 17:30 | Manchester United |  | 1:1 |  | Leicester City | |
| 03 April 2022 | ||||||
| 14:00 | West Ham United |  | 2:1 |  | Everton | |
| 16:30 | Tottenham Hotspur |  | 5:1 |  | Newcastle United | |
| 05 August 2022 | ||||||
| 20:00 | Crystal Palace |  | 3:0 |  | Arsenal | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 30 | 23 | 4 | 3 | 70:18 | 73 |
| 2. |  | Liverpool | 30 | 22 | 6 | 2 | 77:20 | 72 |
| 3. |  | Chelsea | 29 | 17 | 8 | 4 | 58:23 | 59 |
| 4. |  | Tottenham Hotspur | 30 | 17 | 3 | 10 | 52:37 | 54 |
| 5. |  | Arsenal | 29 | 17 | 3 | 9 | 44:34 | 54 |
| 6. |  | West Ham United | 31 | 15 | 6 | 10 | 51:40 | 51 |
| 7. |  | Manchester United | 30 | 14 | 9 | 7 | 49:41 | 51 |
| 8. |  | Wolverhampton Wanderers | 31 | 15 | 4 | 12 | 33:27 | 49 |
| 9. |  | Crystal Palace | 30 | 8 | 13 | 9 | 42:38 | 37 |
| 10. |  | Leicester City | 28 | 10 | 7 | 11 | 43:47 | 37 |
| 11. |  | Aston Villa | 30 | 11 | 3 | 16 | 42:42 | 36 |
| 12. |  | Southampton | 30 | 8 | 12 | 10 | 37:46 | 36 |
| 13. |  | Brighton | 30 | 7 | 13 | 10 | 26:36 | 34 |
| 14. |  | Brentford | 31 | 9 | 6 | 16 | 37:48 | 33 |
| 15. |  | Newcastle United | 30 | 7 | 10 | 13 | 33:54 | 31 |
| 16. |  | Leeds United | 31 | 7 | 9 | 15 | 35:68 | 30 |
| 17. |  | Everton | 28 | 7 | 4 | 17 | 30:49 | 25 |
| 18. |  | Watford | 30 | 6 | 4 | 20 | 29:57 | 22 |
| 19. |  | Burnley | 28 | 3 | 12 | 13 | 22:40 | 21 |
| 20. |  | Norwich City | 30 | 4 | 6 | 20 | 18:63 | 18 |
Stadium: Old Trafford (Manchester), 73,444 audience (97% full)
Season: 2021-22, 31 round, 2022-04-02 17:30
1:1
(0:0)
| 5' |  | Luke Shaw | |
| 16' | | Wesley Fofana | |
| 30' | | Youri Tielemans | |
| 49' | | Scott McTominay | |
| 63' |  | 0:1 | Kelechi Iheanacho |
| 66' | | 1:1 | David de Gea |
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