| 22 May 2022 | ||||||
| 16:00 | Arsenal |  | 5:1 |  | Everton |  |
| 16:00 | Brighton |  | 3:1 |  | West Ham United | |
| 16:00 | Burnley |  | 1:2 |  | Newcastle United | |
| 16:00 | Chelsea |  | 2:1 |  | Watford | |
| 16:00 | Crystal Palace |  | 1:0 |  | Manchester United | |
| 16:00 | Liverpool |  | 3:1 |  | Wolverhampton Wanderers | |
| 16:00 | Manchester City |  | 3:2 |  | Aston Villa | |
| 16:00 | Norwich City |  | 0:5 |  | Tottenham Hotspur | |
| 20 August 2022 | ||||||
| 15:00 | Leicester City |  | 4:1 |  | Southampton | |
| 03 September 2022 | ||||||
| 15:00 | Brentford |  | 1:2 |  | Leeds United | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 38 | 29 | 6 | 3 | 99:26 | 93 |
| 2. |  | Liverpool | 38 | 28 | 8 | 2 | 94:26 | 92 |
| 3. |  | Chelsea | 38 | 21 | 11 | 6 | 76:33 | 74 |
| 4. |  | Tottenham Hotspur | 38 | 22 | 5 | 11 | 69:40 | 71 |
| 5. |  | Arsenal | 38 | 22 | 3 | 13 | 61:48 | 69 |
| 6. |  | Manchester United | 38 | 16 | 10 | 12 | 57:57 | 58 |
| 7. |  | West Ham United | 38 | 16 | 8 | 14 | 60:51 | 56 |
| 8. |  | Leicester City | 38 | 14 | 10 | 14 | 62:59 | 52 |
| 9. |  | Brighton | 38 | 12 | 15 | 11 | 42:44 | 51 |
| 10. |  | Wolverhampton Wanderers | 38 | 15 | 6 | 17 | 38:43 | 51 |
| 11. |  | Newcastle United | 38 | 13 | 10 | 15 | 44:62 | 49 |
| 12. |  | Crystal Palace | 38 | 11 | 15 | 12 | 50:46 | 48 |
| 13. |  | Brentford | 38 | 13 | 7 | 18 | 48:56 | 46 |
| 14. |  | Aston Villa | 38 | 13 | 6 | 19 | 52:54 | 45 |
| 15. |  | Southampton | 38 | 9 | 13 | 16 | 43:67 | 40 |
| 16. |  | Everton | 38 | 11 | 6 | 21 | 43:66 | 39 |
| 17. |  | Leeds United | 38 | 9 | 11 | 18 | 42:79 | 38 |
| 18. |  | Burnley | 38 | 7 | 14 | 17 | 34:53 | 35 |
| 19. |  | Watford | 38 | 6 | 5 | 27 | 34:77 | 23 |
| 20. |  | Norwich City | 38 | 5 | 7 | 26 | 23:84 | 22 |
Stadium: City of Manchester Stadium (Manchester), 53,395 audience (97% full)
Season: 2021-22, 38 round, 2022-05-22 16:00
3:2
(0:1)
| 37' |  | 0:1 | Matty Cash |
| 49' |  | Tyrone Mings | |
| 69' | | 0:2 | Jed Steer |
| 76' | | 1:2 | Ilkay Guendogan |
| 78' | | 2:2 | John Stones |
| 81' | | 3:2 | Ilkay Guendogan |
| 87' | | Marvelous Nakamba |
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