Full statistics between Manchester United and Southampton
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester United | 38 | 28 | 5 | 5 | 86:43 | 89 |
| 2. |  | Manchester City | 38 | 23 | 9 | 6 | 66:34 | 78 |
| 3. |  | Chelsea | 38 | 22 | 9 | 7 | 75:39 | 75 |
| 4. |  | Arsenal | 38 | 21 | 10 | 7 | 72:37 | 73 |
| 5. |  | Tottenham Hotspur | 38 | 21 | 9 | 8 | 66:46 | 72 |
| 6. |  | Everton | 38 | 16 | 15 | 7 | 55:40 | 63 |
| 7. |  | Liverpool | 38 | 16 | 13 | 9 | 71:43 | 61 |
| 8. |  | WBA | 38 | 14 | 7 | 17 | 53:57 | 49 |
| 9. |  | Swansea City | 38 | 11 | 13 | 14 | 47:51 | 46 |
| 10. |  | West Ham United | 38 | 12 | 10 | 16 | 45:53 | 46 |
| 11. |  | Norwich City | 38 | 10 | 14 | 14 | 41:58 | 44 |
| 12. |  | Fulham | 38 | 11 | 10 | 17 | 50:60 | 43 |
| 13. |  | Stoke City | 38 | 9 | 15 | 14 | 34:45 | 42 |
| 14. |  | Southampton | 38 | 9 | 14 | 15 | 49:60 | 41 |
| 15. |  | Aston Villa | 38 | 10 | 11 | 17 | 47:69 | 41 |
| 16. |  | Newcastle United | 38 | 11 | 8 | 19 | 45:68 | 41 |
| 17. |  | Sunderland | 38 | 9 | 12 | 17 | 41:54 | 39 |
| 18. |  | Wigan Athletic | 38 | 9 | 9 | 20 | 47:73 | 36 |
| 19. |  | Reading | 38 | 6 | 10 | 22 | 43:73 | 28 |
| 20. |  | Queens Park Rangers | 38 | 4 | 13 | 21 | 30:60 | 25 |
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