| 28 December 2021 | ||||||
| 15:00 | Crystal Palace |  | 3:0 |  | Norwich City |  |
| 15:00 | Southampton |  | 1:1 |  | Tottenham Hotspur | |
| 15:00 | Watford |  | 1:4 |  | West Ham United | |
| 20:00 | Leicester City |  | 1:0 |  | Liverpool | |
| 29 December 2021 | ||||||
| 19:30 | Chelsea |  | 1:1 |  | Brighton | |
| 20:15 | Brentford |  | 0:1 |  | Manchester City | |
| 30 December 2021 | ||||||
| 20:15 | Manchester United |  | 3:1 |  | Burnley | |
| 24 February 2022 | ||||||
| 19:45 | Arsenal |  | 2:1 |  | Wolverhampton Wanderers | |
| 10 March 2022 | ||||||
| 19:45 | Leeds United |  | 0:3 |  | Aston Villa | |
| 17 March 2022 | ||||||
| 19:45 | Everton |  | 1:0 |  | Newcastle United | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 20 | 16 | 2 | 2 | 51:12 | 50 |
| 2. |  | Chelsea | 20 | 12 | 6 | 2 | 43:14 | 42 |
| 3. |  | Liverpool | 19 | 12 | 5 | 2 | 50:16 | 41 |
| 4. |  | Arsenal | 19 | 11 | 2 | 6 | 32:23 | 35 |
| 5. |  | West Ham United | 19 | 9 | 4 | 6 | 34:25 | 31 |
| 6. |  | Manchester United | 18 | 9 | 4 | 5 | 30:26 | 31 |
| 7. |  | Tottenham Hotspur | 17 | 9 | 3 | 5 | 22:20 | 30 |
| 8. |  | Wolverhampton Wanderers | 18 | 7 | 4 | 7 | 13:14 | 25 |
| 9. |  | Leicester City | 18 | 7 | 4 | 7 | 31:33 | 25 |
| 10. |  | Brighton | 18 | 5 | 9 | 4 | 17:18 | 24 |
| 11. |  | Crystal Palace | 19 | 5 | 8 | 6 | 26:26 | 23 |
| 12. |  | Aston Villa | 18 | 7 | 1 | 10 | 24:28 | 22 |
| 13. |  | Southampton | 19 | 4 | 9 | 6 | 20:29 | 21 |
| 14. |  | Brentford | 18 | 5 | 5 | 8 | 21:25 | 20 |
| 15. |  | Everton | 17 | 5 | 4 | 8 | 20:28 | 19 |
| 16. |  | Leeds United | 18 | 3 | 7 | 8 | 18:36 | 16 |
| 17. |  | Watford | 17 | 4 | 1 | 12 | 22:35 | 13 |
| 18. |  | Burnley | 16 | 1 | 8 | 7 | 15:24 | 11 |
| 19. |  | Newcastle United | 19 | 1 | 8 | 10 | 19:42 | 11 |
| 20. |  | Norwich City | 19 | 2 | 4 | 13 | 8:42 | 10 |
Stadium: St Mary's Stadium (Southampton), 31,304 audience (96% full)
Season: 2021-22, 20 round, 2021-12-28 15:00
1:1
(1:1)
| 13' |  | Kyle Walker-Peters | |
| 25' |  | 1:0 | James Ward-Prowse |
| 27' | | Mohammed Salisu | |
| 39' | | Mohammed Salisu | |
| 39' |  | Mohammed Salisu | |
| 41' |  | 1:1 | Harry Kane |
| 45+1' | | Sergio Reguilón | |
| 51' | | Adam Armstrong | |
| 69' | | Harry Winks |
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