| 30 April 2022 | ||||||
| 12:30 | Newcastle United |  | 0:1 |  | Liverpool |  |
| 15:00 | Aston Villa |  | 2:0 |  | Norwich City | |
| 15:00 | Southampton |  | 1:2 |  | Crystal Palace | |
| 15:00 | Watford |  | 1:2 |  | Burnley | |
| 15:00 | Wolverhampton Wanderers |  | 0:3 |  | Brighton | |
| 17:30 | Leeds United |  | 0:4 |  | Manchester City | |
| 01 May 2022 | ||||||
| 14:00 | Tottenham Hotspur |  | 3:1 |  | Leicester City | |
| 16:30 | West Ham United |  | 1:2 |  | Arsenal | |
| 02 May 2022 | ||||||
| 20:00 | Manchester United |  | 3:0 |  | Brentford | |
| 06 August 2022 | ||||||
| 17:30 | Everton |  | 1:0 |  | Chelsea | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Liverpool | 34 | 25 | 7 | 2 | 86:22 | 82 |
| 2. |  | Manchester City | 33 | 25 | 5 | 3 | 80:21 | 80 |
| 3. |  | Chelsea | 33 | 19 | 9 | 5 | 68:28 | 66 |
| 4. |  | Arsenal | 33 | 19 | 3 | 11 | 52:40 | 60 |
| 5. |  | Tottenham Hotspur | 33 | 18 | 4 | 11 | 56:38 | 58 |
| 6. |  | Manchester United | 35 | 15 | 10 | 10 | 54:52 | 55 |
| 7. |  | West Ham United | 34 | 15 | 7 | 12 | 52:44 | 52 |
| 8. |  | Wolverhampton Wanderers | 34 | 15 | 4 | 15 | 33:32 | 49 |
| 9. |  | Brighton | 35 | 10 | 14 | 11 | 34:42 | 44 |
| 10. |  | Newcastle United | 35 | 11 | 10 | 14 | 40:56 | 43 |
| 11. |  | Leicester City | 32 | 11 | 9 | 12 | 47:51 | 42 |
| 12. |  | Crystal Palace | 34 | 9 | 14 | 11 | 45:42 | 41 |
| 13. |  | Aston Villa | 33 | 12 | 4 | 17 | 44:46 | 40 |
| 14. |  | Brentford | 34 | 11 | 7 | 16 | 41:49 | 40 |
| 15. |  | Southampton | 35 | 9 | 13 | 13 | 41:58 | 40 |
| 16. |  | Burnley | 34 | 7 | 13 | 14 | 31:46 | 34 |
| 17. |  | Leeds United | 33 | 8 | 10 | 15 | 38:68 | 34 |
| 18. |  | Everton | 32 | 8 | 5 | 19 | 34:55 | 29 |
| 19. |  | Watford | 34 | 6 | 4 | 24 | 32:69 | 22 |
| 20. |  | Norwich City | 34 | 5 | 6 | 23 | 22:71 | 21 |
Stadium: Old Trafford (Manchester), 73,482 audience (97% full)
Season: 2021-22, 35 round, 2022-05-02 20:00
3:0
(1:0)
| 9' |  | 1:0 | Bruno Fernandes |
| 54' |  | Nemanja Matić | |
| 61' |  | 2:0 | Cristiano Ronaldo |
| 72' | | 3:0 | Raphaël Varane |
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