| 25 September 2021 | ||||||
| 12:30 | Chelsea |  | 0:1 |  | Manchester City |  |
| 12:30 | Manchester United |  | 0:1 |  | Aston Villa | |
| 15:00 | Everton |  | 2:0 |  | Norwich City | |
| 15:00 | Leeds United |  | 1:2 |  | West Ham United | |
| 15:00 | Leicester City |  | 2:2 |  | Burnley | |
| 15:00 | Watford |  | 1:1 |  | Newcastle United | |
| 17:30 | Brentford |  | 3:3 |  | Liverpool | |
| 26 September 2021 | ||||||
| 14:00 | Southampton |  | 0:1 |  | Wolverhampton Wanderers | |
| 16:30 | Arsenal |  | 3:1 |  | Tottenham Hotspur | |
| 27 September 2021 | ||||||
| 20:00 | Crystal Palace |  | 1:1 |  | Brighton | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Liverpool | 6 | 4 | 2 | 0 | 15:4 | 14 |
| 2. |  | Manchester City | 6 | 4 | 1 | 1 | 12:1 | 13 |
| 3. |  | Chelsea | 6 | 4 | 1 | 1 | 12:2 | 13 |
| 4. |  | Manchester United | 6 | 4 | 1 | 1 | 13:5 | 13 |
| 5. |  | Everton | 6 | 4 | 1 | 1 | 12:7 | 13 |
| 6. |  | Brighton | 6 | 4 | 1 | 1 | 8:5 | 13 |
| 7. |  | West Ham United | 6 | 3 | 2 | 1 | 13:8 | 11 |
| 8. |  | Aston Villa | 6 | 3 | 1 | 2 | 9:7 | 10 |
| 9. |  | Brentford | 6 | 2 | 3 | 1 | 8:5 | 9 |
| 10. |  | Arsenal | 6 | 3 | 0 | 3 | 5:10 | 9 |
| 11. |  | Tottenham Hotspur | 6 | 3 | 0 | 3 | 4:9 | 9 |
| 12. |  | Watford | 6 | 2 | 1 | 3 | 7:9 | 7 |
| 13. |  | Leicester City | 6 | 2 | 1 | 3 | 7:10 | 7 |
| 14. |  | Wolverhampton Wanderers | 6 | 2 | 0 | 4 | 3:5 | 6 |
| 15. |  | Crystal Palace | 6 | 1 | 3 | 2 | 6:9 | 6 |
| 16. |  | Southampton | 6 | 0 | 4 | 2 | 4:7 | 4 |
| 17. |  | Newcastle United | 6 | 0 | 3 | 3 | 7:14 | 3 |
| 18. |  | Leeds United | 6 | 0 | 3 | 3 | 6:14 | 3 |
| 19. |  | Burnley | 6 | 0 | 2 | 4 | 5:11 | 2 |
| 20. |  | Norwich City | 6 | 0 | 0 | 6 | 2:16 | 0 |
Stadium: Selhurst Park (London), 22,975 audience (87% full)
Season: 2021-22, 6 round, 2021-09-27 20:00
1:1
(1:0)
| 28' |  | Adam Lallana | |
| 45+2' |  | 1:0 | Wilfried Zaha |
| 77' | | Marc Cucurella | |
| 81' | | Leandro Trossard | |
| 84' | | Conor Gallagher | |
| 90+5' |  | 1:1 | Neal Maupay |
| 90+7' | | James McArthur | |
| 90+7' | | Robert Sánchez |
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