| 18 December 2021 | ||||||
| 17:30 | Leeds United |  | 1:4 |  | Arsenal |  |
| 19 December 2021 | ||||||
| 14:00 | Wolverhampton Wanderers |  | 0:0 |  | Chelsea | |
| 16:30 | Tottenham Hotspur |  | 2:2 |  | Liverpool | |
| 11 January 2022 | ||||||
| 19:45 | Southampton |  | 4:1 |  | Brentford | |
| 12 January 2022 | ||||||
| 19:45 | West Ham United |  | 2:0 |  | Norwich City | |
| 23 February 2022 | ||||||
| 19:30 | Watford |  | 1:4 |  | Crystal Palace | |
| 20 April 2022 | ||||||
| 19:45 | Everton |  | 1:1 |  | Leicester City | |
| 19 May 2022 | ||||||
| 20:00 | Aston Villa |  | 1:1 |  | Burnley | |
| 07 August 2022 | ||||||
| 14:00 | Manchester United |  | 2:0 |  | Brighton | |
| 21 August 2022 | ||||||
| 16:30 | Newcastle United |  | 0:4 |  | Manchester City | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 18 | 14 | 2 | 2 | 44:9 | 44 |
| 2. |  | Liverpool | 18 | 12 | 5 | 1 | 50:15 | 41 |
| 3. |  | Chelsea | 18 | 11 | 5 | 2 | 39:12 | 38 |
| 4. |  | Arsenal | 18 | 10 | 2 | 6 | 27:23 | 32 |
| 5. |  | West Ham United | 17 | 8 | 4 | 5 | 28:21 | 28 |
| 6. |  | Manchester United | 16 | 8 | 3 | 5 | 26:24 | 27 |
| 7. |  | Tottenham Hotspur | 15 | 8 | 2 | 5 | 18:19 | 26 |
| 8. |  | Wolverhampton Wanderers | 18 | 7 | 4 | 7 | 13:14 | 25 |
| 9. |  | Leicester City | 16 | 6 | 4 | 6 | 27:27 | 22 |
| 10. |  | Aston Villa | 17 | 7 | 1 | 9 | 23:25 | 22 |
| 11. |  | Crystal Palace | 17 | 4 | 8 | 5 | 23:23 | 20 |
| 12. |  | Brentford | 16 | 5 | 5 | 6 | 21:22 | 20 |
| 13. |  | Brighton | 16 | 4 | 8 | 4 | 14:17 | 20 |
| 14. |  | Everton | 17 | 5 | 4 | 8 | 20:28 | 19 |
| 15. |  | Southampton | 17 | 3 | 8 | 6 | 16:26 | 17 |
| 16. |  | Leeds United | 18 | 3 | 7 | 8 | 18:36 | 16 |
| 17. |  | Watford | 16 | 4 | 1 | 11 | 21:31 | 13 |
| 18. |  | Burnley | 15 | 1 | 8 | 6 | 14:21 | 11 |
| 19. |  | Newcastle United | 18 | 1 | 7 | 10 | 18:41 | 10 |
| 20. |  | Norwich City | 17 | 2 | 4 | 11 | 8:34 | 10 |
Stadium: St Mary's Stadium (Southampton), 27,383 audience (84% full)
Season: 2021-22, 18 round, 2022-01-11 19:45
4:1
(2:1)
| 5' |  | 1:0 | Jan Bednarek |
| 23' | | 1:1 | Vitaly Janelt |
| 37' |  | 2:1 | Álvaro Fernández |
| 45+2' |  | Ivan Toney | |
| 49' | | 3:1 | Armando Broja |
| 70' | | 4:1 | Che Adams |
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