| 16 April 2022 | ||||||
| 12:30 | Tottenham Hotspur |  | 0:1 |  | Brighton |  |
| 15:00 | Manchester United |  | 3:2 |  | Norwich City | |
| 15:00 | Southampton |  | 1:0 |  | Arsenal | |
| 15:00 | Watford |  | 1:2 |  | Brentford | |
| 17 April 2022 | ||||||
| 14:15 | Newcastle United |  | 2:1 |  | Leicester City | |
| 14:15 | West Ham United |  | 1:1 |  | Burnley | |
| 10 May 2022 | ||||||
| 20:00 | Aston Villa |  | 1:2 |  | Liverpool | |
| 11 May 2022 | ||||||
| 20:15 | Wolverhampton Wanderers |  | 1:5 |  | Manchester City | |
| 19 May 2022 | ||||||
| 19:45 | Everton |  | 3:2 |  | Crystal Palace | |
| 21 August 2022 | ||||||
| 14:00 | Leeds United |  | 0:3 |  | Chelsea | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Liverpool | 32 | 23 | 7 | 2 | 83:22 | 76 |
| 2. |  | Manchester City | 31 | 23 | 5 | 3 | 72:20 | 74 |
| 3. |  | Chelsea | 30 | 18 | 8 | 4 | 64:23 | 62 |
| 4. |  | Tottenham Hotspur | 32 | 18 | 3 | 11 | 56:38 | 57 |
| 5. |  | Arsenal | 31 | 17 | 3 | 11 | 45:37 | 54 |
| 6. |  | Manchester United | 33 | 15 | 9 | 9 | 52:48 | 54 |
| 7. |  | West Ham United | 33 | 15 | 7 | 11 | 52:43 | 52 |
| 8. |  | Wolverhampton Wanderers | 32 | 15 | 4 | 13 | 33:28 | 49 |
| 9. |  | Leicester City | 30 | 11 | 7 | 12 | 46:50 | 40 |
| 10. |  | Brighton | 32 | 9 | 13 | 10 | 29:37 | 40 |
| 11. |  | Brentford | 33 | 11 | 6 | 16 | 41:49 | 39 |
| 12. |  | Southampton | 32 | 9 | 12 | 11 | 38:52 | 39 |
| 13. |  | Crystal Palace | 31 | 8 | 13 | 10 | 43:40 | 37 |
| 14. |  | Newcastle United | 32 | 9 | 10 | 13 | 36:55 | 37 |
| 15. |  | Aston Villa | 31 | 11 | 3 | 17 | 42:46 | 36 |
| 16. |  | Leeds United | 32 | 8 | 9 | 15 | 38:68 | 33 |
| 17. |  | Everton | 30 | 8 | 4 | 18 | 33:52 | 28 |
| 18. |  | Burnley | 31 | 4 | 13 | 14 | 26:45 | 25 |
| 19. |  | Watford | 32 | 6 | 4 | 22 | 30:62 | 22 |
| 20. |  | Norwich City | 32 | 5 | 6 | 21 | 22:66 | 21 |
Stadium: Old Trafford (Manchester), 73,381 audience (97% full)
Season: 2021-22, 33 round, 2022-04-16 15:00
3:2
(2:1)
| 7' |  | 1:0 | Cristiano Ronaldo |
| 32' | | 2:0 | Cristiano Ronaldo |
| 45+1' | | 2:1 | Kieran Dowell |
| 52' | | 2:2 | Teemu Pukki |
| 76' | | 3:2 | Cristiano Ronaldo |
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