| 10 December 2021 | ||||||
| 20:00 | Brentford |  | 2:1 |  | Watford |  |
| 11 December 2021 | ||||||
| 12:30 | Manchester City |  | 1:0 |  | Wolverhampton Wanderers | |
| 15:00 | Arsenal |  | 3:0 |  | Southampton | |
| 15:00 | Chelsea |  | 3:2 |  | Leeds United | |
| 15:00 | Liverpool |  | 1:0 |  | Aston Villa | |
| 17:30 | Norwich City |  | 0:1 |  | Manchester United | |
| 12 December 2021 | ||||||
| 14:00 | Burnley |  | 0:0 |  | West Ham United | |
| 14:00 | Leicester City |  | 4:0 |  | Newcastle United | |
| 16:30 | Crystal Palace |  | 3:1 |  | Everton | |
| 16 March 2022 | ||||||
| 19:30 | Brighton |  | 0:2 |  | Tottenham Hotspur | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 16 | 12 | 2 | 2 | 33:9 | 38 |
| 2. |  | Liverpool | 16 | 11 | 4 | 1 | 45:12 | 37 |
| 3. |  | Chelsea | 16 | 11 | 3 | 2 | 38:11 | 36 |
| 4. |  | West Ham United | 16 | 8 | 4 | 4 | 28:19 | 28 |
| 5. |  | Manchester United | 16 | 8 | 3 | 5 | 26:24 | 27 |
| 6. |  | Arsenal | 16 | 8 | 2 | 6 | 21:22 | 26 |
| 7. |  | Tottenham Hotspur | 14 | 8 | 1 | 5 | 16:17 | 25 |
| 8. |  | Leicester City | 16 | 6 | 4 | 6 | 27:27 | 22 |
| 9. |  | Wolverhampton Wanderers | 16 | 6 | 3 | 7 | 12:14 | 21 |
| 10. |  | Brentford | 16 | 5 | 5 | 6 | 21:22 | 20 |
| 11. |  | Brighton | 15 | 4 | 8 | 3 | 14:16 | 20 |
| 12. |  | Crystal Palace | 16 | 4 | 7 | 5 | 21:21 | 19 |
| 13. |  | Aston Villa | 16 | 6 | 1 | 9 | 21:25 | 19 |
| 14. |  | Everton | 16 | 5 | 3 | 8 | 19:27 | 18 |
| 15. |  | Leeds United | 16 | 3 | 7 | 6 | 17:25 | 16 |
| 16. |  | Southampton | 16 | 3 | 7 | 6 | 14:24 | 16 |
| 17. |  | Watford | 16 | 4 | 1 | 11 | 21:31 | 13 |
| 18. |  | Burnley | 15 | 1 | 8 | 6 | 14:21 | 11 |
| 19. |  | Newcastle United | 16 | 1 | 7 | 8 | 17:34 | 10 |
| 20. |  | Norwich City | 16 | 2 | 4 | 10 | 8:32 | 10 |
Stadium: City of Manchester Stadium (Manchester), 52,613 audience (95% full)
Season: 2021-22, 16 round, 2021-12-11 12:30
1:0
(0:0)
| 40' |  | Rúben Dias | |
| 43' | | Rodrigo | |
| 45+1' | | Raúl Jiménez | |
| 45+2' |  | Raúl Jiménez | |
| 45+3' | | Rúben Neves | |
| 66' |  | 1:0 | Raheem Sterling |
| 78' | | Leander Dendoncker | |
| 81' | | João Cancelo |
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