| 20 November 2021 | ||||||
| 12:30 | Leicester City |  | 0:3 |  | Chelsea |  |
| 15:00 | Aston Villa |  | 2:0 |  | Brighton | |
| 15:00 | Burnley |  | 3:3 |  | Crystal Palace | |
| 15:00 | Newcastle United |  | 3:3 |  | Brentford | |
| 15:00 | Norwich City |  | 2:1 |  | Southampton | |
| 15:00 | Watford |  | 4:1 |  | Manchester United | |
| 15:00 | Wolverhampton Wanderers |  | 1:0 |  | West Ham United | |
| 17:30 | Liverpool |  | 4:0 |  | Arsenal | |
| 21 November 2021 | ||||||
| 14:00 | Manchester City |  | 3:0 |  | Everton | |
| 16:30 | Tottenham Hotspur |  | 2:1 |  | Leeds United | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Chelsea | 12 | 9 | 2 | 1 | 30:4 | 29 |
| 2. |  | Manchester City | 12 | 8 | 2 | 2 | 25:6 | 26 |
| 3. |  | Liverpool | 12 | 7 | 4 | 1 | 35:11 | 25 |
| 4. |  | West Ham United | 12 | 7 | 2 | 3 | 23:14 | 23 |
| 5. |  | Arsenal | 12 | 6 | 2 | 4 | 13:17 | 20 |
| 6. |  | Wolverhampton Wanderers | 12 | 6 | 1 | 5 | 12:12 | 19 |
| 7. |  | Tottenham Hotspur | 12 | 6 | 1 | 5 | 11:17 | 19 |
| 8. |  | Manchester United | 12 | 5 | 2 | 5 | 20:21 | 17 |
| 9. |  | Brighton | 12 | 4 | 5 | 3 | 12:14 | 17 |
| 10. |  | Crystal Palace | 12 | 3 | 7 | 2 | 18:17 | 16 |
| 11. |  | Everton | 12 | 4 | 3 | 5 | 16:19 | 15 |
| 12. |  | Leicester City | 12 | 4 | 3 | 5 | 16:21 | 15 |
| 13. |  | Southampton | 12 | 3 | 5 | 4 | 11:14 | 14 |
| 14. |  | Brentford | 12 | 3 | 4 | 5 | 16:17 | 13 |
| 15. |  | Aston Villa | 12 | 4 | 1 | 7 | 16:20 | 13 |
| 16. |  | Watford | 12 | 4 | 1 | 7 | 16:20 | 13 |
| 17. |  | Leeds United | 12 | 2 | 5 | 5 | 12:20 | 11 |
| 18. |  | Burnley | 12 | 1 | 6 | 5 | 14:20 | 9 |
| 19. |  | Norwich City | 12 | 2 | 2 | 8 | 7:27 | 8 |
| 20. |  | Newcastle United | 12 | 0 | 6 | 6 | 15:27 | 6 |
Stadium: City of Manchester Stadium (Manchester), 52,571 audience (95% full)
Season: 2021-22, 12 round, 2021-11-21 14:00
3:0
(1:0)
| 31' |  | Richarlison | |
| 44' |  | 1:0 | Raheem Sterling |
| 45+3' | | Aymeric Laporte | |
| 55' | | 2:0 | Rodrigo |
| 86' | | 3:0 | Bernardo Silva |
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