| 14 December 2021 | ||||||
| 19:45 | Norwich City |  | 0:2 |  | Aston Villa |  |
| 20:00 | Manchester City |  | 7:0 |  | Leeds United | |
| 15 December 2021 | ||||||
| 19:30 | Brighton |  | 0:1 |  | Wolverhampton Wanderers | |
| 19:30 | Crystal Palace |  | 2:2 |  | Southampton | |
| 20:00 | Arsenal |  | 2:0 |  | West Ham United | |
| 16 December 2021 | ||||||
| 19:45 | Chelsea |  | 1:1 |  | Everton | |
| 19 January 2022 | ||||||
| 19:30 | Leicester City |  | 2:3 |  | Tottenham Hotspur | |
| 05 February 2022 | ||||||
| 18:00 | Burnley |  | 0:0 |  | Watford | |
| 13 August 2022 | ||||||
| 17:30 | Brentford |  | 1:3 |  | Manchester United | |
| 31 August 2022 | ||||||
| 20:00 | Liverpool |  | 3:1 |  | Newcastle United | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 17 | 13 | 2 | 2 | 40:9 | 41 |
| 2. |  | Liverpool | 17 | 12 | 4 | 1 | 48:13 | 40 |
| 3. |  | Chelsea | 17 | 11 | 4 | 2 | 39:12 | 37 |
| 4. |  | Arsenal | 17 | 9 | 2 | 6 | 23:22 | 29 |
| 5. |  | West Ham United | 17 | 8 | 4 | 5 | 28:21 | 28 |
| 6. |  | Manchester United | 16 | 8 | 3 | 5 | 26:24 | 27 |
| 7. |  | Tottenham Hotspur | 14 | 8 | 1 | 5 | 16:17 | 25 |
| 8. |  | Wolverhampton Wanderers | 17 | 7 | 3 | 7 | 13:14 | 24 |
| 9. |  | Leicester City | 16 | 6 | 4 | 6 | 27:27 | 22 |
| 10. |  | Aston Villa | 17 | 7 | 1 | 9 | 23:25 | 22 |
| 11. |  | Crystal Palace | 17 | 4 | 8 | 5 | 23:23 | 20 |
| 12. |  | Brentford | 16 | 5 | 5 | 6 | 21:22 | 20 |
| 13. |  | Brighton | 16 | 4 | 8 | 4 | 14:17 | 20 |
| 14. |  | Everton | 17 | 5 | 4 | 8 | 20:28 | 19 |
| 15. |  | Southampton | 17 | 3 | 8 | 6 | 16:26 | 17 |
| 16. |  | Leeds United | 17 | 3 | 7 | 7 | 17:32 | 16 |
| 17. |  | Watford | 16 | 4 | 1 | 11 | 21:31 | 13 |
| 18. |  | Burnley | 15 | 1 | 8 | 6 | 14:21 | 11 |
| 19. |  | Newcastle United | 17 | 1 | 7 | 9 | 18:37 | 10 |
| 20. |  | Norwich City | 17 | 2 | 4 | 11 | 8:34 | 10 |
Stadium: Anfield (Liverpool), 52,951 audience (98% full)
Season: 2021-22, 17 round, 2022-08-31 20:00
3:1
(2:1)
| 7' |  | 0:1 | Jonjo Shelvey |
| 21' | | 1:1 | Diogo Jota |
| 25' | | 2:1 | Mohamed Salah |
| 45+2' |  | Joelinton | |
| 55' | | Ryan Fraser | |
| 70' | | Jordan Henderson | |
| 86' | | Isaac Hayden | |
| 87' | | 3:1 | Trent Alexander-Arnold |
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