| 27 November 2020 | ||||||
| 20:00 | Crystal Palace |  | 0:2 |  | Newcastle United |  |
| 28 November 2020 | ||||||
| 12:30 | Brighton |  | 1:1 |  | Liverpool | |
| 15:00 | Manchester City |  | 5:0 |  | Burnley | |
| 17:30 | Everton |  | 0:1 |  | Leeds United | |
| 20:00 | WBA |  | 1:0 |  | Sheffield United | |
| 29 November 2020 | ||||||
| 16:30 | Chelsea |  | 0:0 |  | Tottenham Hotspur | |
| 19:15 | Arsenal |  | 1:2 |  | Wolverhampton Wanderers | |
| 30 November 2020 | ||||||
| 17:30 | Leicester City |  | 1:2 |  | Fulham | |
| 20:00 | West Ham United |  | 2:1 |  | Aston Villa | |
| 22 August 2021 | ||||||
| 14:00 | Southampton |  | 2:3 |  | Manchester United | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Tottenham Hotspur | 10 | 6 | 3 | 1 | 21:9 | 21 |
| 2. |  | Liverpool | 10 | 6 | 3 | 1 | 22:17 | 21 |
| 3. |  | Chelsea | 10 | 5 | 4 | 1 | 22:10 | 19 |
| 4. |  | Leicester City | 10 | 6 | 0 | 4 | 19:14 | 18 |
| 5. |  | West Ham United | 10 | 5 | 2 | 3 | 17:11 | 17 |
| 6. |  | Southampton | 10 | 5 | 2 | 3 | 19:16 | 17 |
| 7. |  | Wolverhampton Wanderers | 10 | 5 | 2 | 3 | 11:11 | 17 |
| 8. |  | Everton | 10 | 5 | 1 | 4 | 19:17 | 16 |
| 9. |  | Manchester United | 9 | 5 | 1 | 3 | 16:16 | 16 |
| 10. |  | Aston Villa | 9 | 5 | 0 | 4 | 20:13 | 15 |
| 11. |  | Manchester City | 9 | 4 | 3 | 2 | 15:11 | 15 |
| 12. |  | Leeds United | 10 | 4 | 2 | 4 | 15:17 | 14 |
| 13. |  | Newcastle United | 10 | 4 | 2 | 4 | 12:15 | 14 |
| 14. |  | Arsenal | 10 | 4 | 1 | 5 | 10:12 | 13 |
| 15. |  | Crystal Palace | 10 | 4 | 1 | 5 | 12:15 | 13 |
| 16. |  | Brighton | 10 | 2 | 4 | 4 | 14:16 | 10 |
| 17. |  | Fulham | 10 | 2 | 1 | 7 | 11:19 | 7 |
| 18. |  | WBA | 10 | 1 | 3 | 6 | 7:18 | 6 |
| 19. |  | Burnley | 9 | 1 | 2 | 6 | 4:17 | 5 |
| 20. |  | Sheffield United | 10 | 0 | 1 | 9 | 4:16 | 1 |
Stadium: St Mary's Stadium (Southampton)
Season: 2020-21, 10 round, 2021-08-22 14:00
2:3
(2:0)
| 16' |  | James Ward-Prowse | |
| 23' |  | 1:0 | Jan Bednarek |
| 33' | | 2:0 | James Ward-Prowse |
| 59' | | 2:1 | Bruno Fernandes |
| 74' | | 2:2 | Edinson Cavani |
| 90+3' | | 2:3 | Edinson Cavani |
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