| 01 January 2022 | ||||||
| 12:30 | Arsenal |  | 1:2 |  | Manchester City |  |
| 15:00 | Watford |  | 0:1 |  | Tottenham Hotspur | |
| 17:30 | Crystal Palace |  | 2:3 |  | West Ham United | |
| 02 January 2022 | ||||||
| 14:00 | Brentford |  | 2:1 |  | Aston Villa | |
| 14:00 | Everton |  | 2:3 |  | Brighton | |
| 14:00 | Leeds United |  | 3:1 |  | Burnley | |
| 16:30 | Chelsea |  | 2:2 |  | Liverpool | |
| 03 January 2022 | ||||||
| 17:30 | Manchester United |  | 0:1 |  | Wolverhampton Wanderers | |
| 10 March 2022 | ||||||
| 19:30 | Southampton |  | 1:2 |  | Newcastle United | |
| 11 May 2022 | ||||||
| 19:45 | Leicester City |  | 3:0 |  | Norwich City | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 21 | 17 | 2 | 2 | 53:13 | 53 |
| 2. |  | Chelsea | 21 | 12 | 7 | 2 | 45:16 | 43 |
| 3. |  | Liverpool | 20 | 12 | 6 | 2 | 52:18 | 42 |
| 4. |  | West Ham United | 21 | 11 | 4 | 6 | 39:27 | 37 |
| 5. |  | Arsenal | 20 | 11 | 2 | 7 | 33:25 | 35 |
| 6. |  | Tottenham Hotspur | 18 | 10 | 3 | 5 | 23:20 | 33 |
| 7. |  | Manchester United | 19 | 9 | 4 | 6 | 30:27 | 31 |
| 8. |  | Wolverhampton Wanderers | 19 | 8 | 4 | 7 | 14:14 | 28 |
| 9. |  | Brighton | 19 | 6 | 9 | 4 | 20:20 | 27 |
| 10. |  | Leicester City | 18 | 7 | 4 | 7 | 31:33 | 25 |
| 11. |  | Southampton | 20 | 5 | 9 | 6 | 24:30 | 24 |
| 12. |  | Crystal Palace | 20 | 5 | 8 | 7 | 28:29 | 23 |
| 13. |  | Brentford | 20 | 6 | 5 | 9 | 24:30 | 23 |
| 14. |  | Aston Villa | 19 | 7 | 1 | 11 | 25:30 | 22 |
| 15. |  | Everton | 18 | 5 | 4 | 9 | 22:31 | 19 |
| 16. |  | Leeds United | 19 | 4 | 7 | 8 | 21:37 | 19 |
| 17. |  | Watford | 18 | 4 | 1 | 13 | 22:36 | 13 |
| 18. |  | Burnley | 17 | 1 | 8 | 8 | 16:27 | 11 |
| 19. |  | Newcastle United | 19 | 1 | 8 | 10 | 19:42 | 11 |
| 20. |  | Norwich City | 20 | 2 | 4 | 14 | 8:44 | 10 |
Stadium: Old Trafford (Manchester), 73,045 audience (96% full)
Season: 2021-22, 21 round, 2022-01-03 17:30
0:1
(0:0)
| 48' |  | Scott McTominay | |
| 56' | | Luke Shaw | |
| 74' | | Nemanja Matić | |
| 82' |  | 0:1 | Joao Moutinho |
| 90+4' | | José Sá |
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