| 13 August 2021 | ||||||
| 20:00 | Brentford |  | 2:0 |  | Arsenal |  |
| 14 August 2021 | ||||||
| 12:30 | Manchester United |  | 5:1 |  | Leeds United | |
| 15:00 | Burnley |  | 1:2 |  | Brighton | |
| 15:00 | Chelsea |  | 3:0 |  | Crystal Palace | |
| 15:00 | Everton |  | 3:1 |  | Southampton | |
| 15:00 | Leicester City |  | 1:0 |  | Wolverhampton Wanderers | |
| 15:00 | Watford |  | 3:2 |  | Aston Villa | |
| 17:30 | Norwich City |  | 0:3 |  | Liverpool | |
| 15 August 2021 | ||||||
| 14:00 | Newcastle United |  | 2:4 |  | West Ham United | |
| 16:30 | Tottenham Hotspur |  | 1:0 |  | Manchester City | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester United | 1 | 1 | 0 | 0 | 5:1 | 3 |
| 2. |  | Chelsea | 1 | 1 | 0 | 0 | 3:0 | 3 |
| 3. |  | Liverpool | 1 | 1 | 0 | 0 | 3:0 | 3 |
| 4. |  | West Ham United | 1 | 1 | 0 | 0 | 4:2 | 3 |
| 5. |  | Everton | 1 | 1 | 0 | 0 | 3:1 | 3 |
| 6. |  | Brentford | 1 | 1 | 0 | 0 | 2:0 | 3 |
| 7. |  | Watford | 1 | 1 | 0 | 0 | 3:2 | 3 |
| 8. |  | Brighton | 1 | 1 | 0 | 0 | 2:1 | 3 |
| 9. |  | Leicester City | 1 | 1 | 0 | 0 | 1:0 | 3 |
| 10. |  | Tottenham Hotspur | 1 | 1 | 0 | 0 | 1:0 | 3 |
| 11. |  | Aston Villa | 1 | 0 | 0 | 1 | 2:3 | 0 |
| 12. |  | Burnley | 1 | 0 | 0 | 1 | 1:2 | 0 |
| 13. |  | Manchester City | 1 | 0 | 0 | 1 | 0:1 | 0 |
| 14. |  | Wolverhampton Wanderers | 1 | 0 | 0 | 1 | 0:1 | 0 |
| 15. |  | Newcastle United | 1 | 0 | 0 | 1 | 2:4 | 0 |
| 16. |  | Southampton | 1 | 0 | 0 | 1 | 1:3 | 0 |
| 17. |  | Arsenal | 1 | 0 | 0 | 1 | 0:2 | 0 |
| 18. |  | Crystal Palace | 1 | 0 | 0 | 1 | 0:3 | 0 |
| 19. |  | Norwich City | 1 | 0 | 0 | 1 | 0:3 | 0 |
| 20. |  | Leeds United | 1 | 0 | 0 | 1 | 1:5 | 0 |
Stadium: Old Trafford (Manchester), 72,732 audience (96% full)
Season: 2021-22, 1 round, 2021-08-14 12:30
5:1
(1:0)
| 30' |  | 1:0 | Bruno Fernandes |
| 48' | | 1:1 | Luke Ayling |
| 52' | | 2:1 | Mason Greenwood |
| 54' | | 3:1 | Bruno Fernandes |
| 59' |  | Liam Cooper | |
| 60' | | 4:1 | Bruno Fernandes |
| 62' | | Raphinha | |
| 68' | | 5:1 | Fred |
| 83' | | Luke Shaw |
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