| 04 December 2021 | ||||||
| 12:30 | West Ham United |  | 3:2 |  | Chelsea |  |
| 15:00 | Newcastle United |  | 1:0 |  | Burnley | |
| 15:00 | Southampton |  | 1:1 |  | Brighton | |
| 15:00 | Wolverhampton Wanderers |  | 0:1 |  | Liverpool | |
| 17:30 | Watford |  | 1:3 |  | Manchester City | |
| 05 December 2021 | ||||||
| 14:00 | Leeds United |  | 2:2 |  | Brentford | |
| 14:00 | Manchester United |  | 1:0 |  | Crystal Palace | |
| 14:00 | Tottenham Hotspur |  | 3:0 |  | Norwich City | |
| 16:30 | Aston Villa |  | 2:1 |  | Leicester City | |
| 06 December 2021 | ||||||
| 20:00 | Everton |  | 2:1 |  | Arsenal | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 15 | 11 | 2 | 2 | 32:9 | 35 |
| 2. |  | Liverpool | 15 | 10 | 4 | 1 | 44:12 | 34 |
| 3. |  | Chelsea | 15 | 10 | 3 | 2 | 35:9 | 33 |
| 4. |  | West Ham United | 15 | 8 | 3 | 4 | 28:19 | 27 |
| 5. |  | Tottenham Hotspur | 14 | 8 | 1 | 5 | 16:17 | 25 |
| 6. |  | Manchester United | 15 | 7 | 3 | 5 | 25:24 | 24 |
| 7. |  | Arsenal | 15 | 7 | 2 | 6 | 18:22 | 23 |
| 8. |  | Wolverhampton Wanderers | 15 | 6 | 3 | 6 | 12:13 | 21 |
| 9. |  | Brighton | 15 | 4 | 8 | 3 | 14:16 | 20 |
| 10. |  | Aston Villa | 15 | 6 | 1 | 8 | 21:24 | 19 |
| 11. |  | Leicester City | 15 | 5 | 4 | 6 | 23:27 | 19 |
| 12. |  | Everton | 15 | 5 | 3 | 7 | 19:25 | 18 |
| 13. |  | Brentford | 15 | 4 | 5 | 6 | 19:21 | 17 |
| 14. |  | Crystal Palace | 15 | 3 | 7 | 5 | 19:21 | 16 |
| 15. |  | Leeds United | 15 | 3 | 7 | 5 | 15:22 | 16 |
| 16. |  | Southampton | 15 | 3 | 7 | 5 | 14:21 | 16 |
| 17. |  | Watford | 15 | 4 | 1 | 10 | 20:29 | 13 |
| 18. |  | Burnley | 14 | 1 | 7 | 6 | 14:21 | 10 |
| 19. |  | Newcastle United | 15 | 1 | 7 | 7 | 17:30 | 10 |
| 20. |  | Norwich City | 15 | 2 | 4 | 9 | 8:31 | 10 |
Stadium: Old Trafford (Manchester), 73,172 audience (97% full)
Season: 2021-22, 15 round, 2021-12-05 14:00
1:0
(0:0)
| 31' |  | Nathaniel Clyne | |
| 67' | | Marc Guéhi | |
| 77' |  | 1:0 | Fred |
| 81' | | Scott McTominay | |
| 90+1' | | Victor Lindelöf |
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