| 25 February 2022 | ||||||
| 20:00 | Southampton |  | 2:0 |  | Norwich City |  |
| 26 February 2022 | ||||||
| 12:30 | Leeds United |  | 0:4 |  | Tottenham Hotspur | |
| 15:00 | Brentford |  | 0:2 |  | Newcastle United | |
| 15:00 | Brighton |  | 0:2 |  | Aston Villa | |
| 15:00 | Crystal Palace |  | 1:1 |  | Burnley | |
| 15:00 | Manchester United |  | 0:0 |  | Watford | |
| 17:30 | Everton |  | 0:1 |  | Manchester City | |
| 27 February 2022 | ||||||
| 14:00 | West Ham United |  | 1:0 |  | Wolverhampton Wanderers | |
| 16 March 2022 | ||||||
| 20:15 | Arsenal |  | 0:2 |  | Liverpool | |
| 27 August 2022 | ||||||
| 15:00 | Chelsea |  | 1:1 |  | Leicester City | |
| # | Club | T | W | D | L | GD | P | |
| 1. |  | Manchester City | 27 | 21 | 3 | 3 | 64:17 | 66 |
| 2. |  | Liverpool | 26 | 18 | 6 | 2 | 70:20 | 60 |
| 3. |  | Chelsea | 25 | 14 | 8 | 3 | 49:18 | 50 |
| 4. |  | Manchester United | 27 | 13 | 8 | 6 | 44:34 | 47 |
| 5. |  | West Ham United | 27 | 13 | 6 | 8 | 46:34 | 45 |
| 6. |  | Arsenal | 24 | 14 | 3 | 7 | 38:27 | 45 |
| 7. |  | Tottenham Hotspur | 25 | 13 | 3 | 9 | 35:32 | 42 |
| 8. |  | Wolverhampton Wanderers | 26 | 12 | 4 | 10 | 24:21 | 40 |
| 9. |  | Southampton | 26 | 8 | 11 | 7 | 34:37 | 35 |
| 10. |  | Brighton | 26 | 7 | 12 | 7 | 25:30 | 33 |
| 11. |  | Crystal Palace | 27 | 6 | 12 | 9 | 37:38 | 30 |
| 12. |  | Aston Villa | 25 | 9 | 3 | 13 | 33:37 | 30 |
| 13. |  | Leicester City | 23 | 7 | 6 | 10 | 37:43 | 27 |
| 14. |  | Newcastle United | 25 | 5 | 10 | 10 | 28:45 | 25 |
| 15. |  | Brentford | 27 | 6 | 6 | 15 | 27:44 | 24 |
| 16. |  | Leeds United | 26 | 5 | 8 | 13 | 29:60 | 23 |
| 17. |  | Everton | 24 | 6 | 4 | 14 | 28:41 | 22 |
| 18. |  | Burnley | 24 | 3 | 12 | 9 | 22:30 | 21 |
| 19. |  | Watford | 26 | 5 | 4 | 17 | 25:47 | 19 |
| 20. |  | Norwich City | 26 | 4 | 5 | 17 | 15:55 | 17 |
Stadium: Griffin Park (London), 17,039 audience (139% full)
Season: 2021-22, 27 round, 2022-02-26 15:00
0:2
(0:2)
| 11' |  | Josh Dasilva | |
| 33' |  | 0:1 | Ciaran Clark |
| 44' | | 0:2 | Joe Willock |
| 45+1' |  | Kristoffer Ajer | |
| 68' | | Martin Dubravka | |
| 84' | | Bryan Mbeumo | |
| 90+5' | | Vitaly Janelt |
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